I’ve been messing around for two days now getting Vista Business installed on my work PC. So far, Adobe Reader 8.0 is the only application I’ve had real trouble with. Adobe’s installer is ignorant and will not work if you have User Account Control (UAC) disabled. UAC was causing me serious headaches with Synergy2 so I disabled it in a heartbeat, but the Adobe Reader 8 installer would always fail with an error about the Temp directory on the drive being full. I knew that was hogwash, so to Google I turned where I found this Adobe TechNote explaining that you had to turn UAC ON if you wanted to install Adobe Reader 8, and then you can turn it back off if you like. The other workaround was much simpler: right-click the installer and go to Properties, click the Compatibility tab, and check the “Run this program in compatibility mode for:” box and make sure Windows XP is selected.
I’ll post more thoughts on Vista at a later time. Hope this helps someone else.